Could Mounjaro® or Wegovy® be affecting your HRT? Here’s what every woman needs to know.
If you’re taking Mounjaro® (tirzepatide) or Wegovy® (semaglutide) to manage weight loss or type 2 diabetes—and you’re also on HRT—you need to be aware of the following:
The British Menopause Society has announced an important issue that could affect your hormone therapy without you even realising it.
At Essex Menopause Clinic, we’re passionate about making sure you’re fully informed and properly protected when it comes to your HRT—especially as new medications become part of modern health care.
Here’s everything you need to know, explained simply, clearly, and with all the practical steps you need to stay safe.
How Mounjaro® and Wegovy® Can Affect Your HRT
Both Mounjaro® and Wegovy® belong to a class of medications called GLP-1 receptor agonists. They are highly effective for:
- Reducing appetite
- Helping with blood sugar control
- Supporting significant, sustainable weight loss
One of the ways they work is by slowing down the emptying of your stomach (called delayed gastric emptying).
And while that’s fantastic for helping you feel fuller for longer, it also means any medication you swallow—including oral HRT tablets—may not absorb properly.
The part of HRT we’re particularly concerned about is oral progesterone (e.g., Utrogestan®).
Progesterone plays a vital role in protecting your womb lining (endometrium) if you’re taking oestrogen. If the progesterone isn’t properly absorbed, your womb lining could build up, putting you at risk of heavy bleeding, abnormal bleeding, or even endometrial cancer.
In short:
Your HRT might stop working properly
You might bleed again after years without a period
You might unknowingly increase your risk of womb problems
The New BMS Advice: What Should You Be Aware Of?
The BMS has issued new interim guidelines specifically for women on Mounjaro®, Wegovy® and other GLP-1 medications.
Here’s what you need to know:
- You may need to switch your oral oestrogen to a transdermal route
- Instead of taking oestrogen tablets, we can prescribe patches, gels, or sprays applied to the skin.
- These are absorbed directly into the bloodstream, bypassing the digestive system entirely.
- You may need to switch to a non-oral form of progesterone
- The best option? A Mirena® coil fitted in the womb.
It releases progesterone exactly where it’s needed and gives reliable, consistent protection. At Essex Menopause Clinic, we fit Mirena® coils, so book at consultation to discuss with us.
- If you stay on oral progesterone (like Utrogestan®) you may need to temporarily increase your progesterone dose.
- When starting Mounjaro® or Wegovy®—or when the dose increases—we may need to double your oral progesterone dose for 4 weeks.
- This helps ensure your womb remains protected during the crucial period when absorption might be reduced. Please book an appointment to discuss this – never change your dose without first discussing it with a doctor.
Real-World Experience: Why We’re Acting Fast at Essex Menopause Clinic
We’ve already seen real-life examples:
Women who had been stable and symptom-free on their HRT for years suddenly began bleeding after starting Wegovy® or Mounjaro®, even though they were taking their medications correctly.
On investigating, it became clear that the problem wasn’t their oestrogen or progesterone—it was their body’s ability to absorb it.
We want to protect you from going through this.
That’s why we are proactively reviewing all our Essex Menopause Clinic patients who are considering—or already using—GLP-1 medications.
What Are the Warning Signs to Watch Out For?
If you’re on HRT and Mounjaro®/Wegovy®, please contact us if you notice any of the following:
- Fresh bleeding after months or years without a period
- Spotting between periods
- Unusual pelvic discomfort or bloating
- Changes in discharge or unusual pain
Don’t ignore these signs.
Early investigation allows us to act quickly and protect your long-term health.
How We Help: Specialist Menopause Care You Can Trust
At Essex Menopause Clinic, we don’t believe in one-size-fits-all HRT.
We offer tailored menopause and midlife hormone care that always puts your unique health journey at the centre.
Here’s how we can support you:
🩺 Specialist Menopause Reviews
A full check of your symptoms, history, risks, and medications—including reviewing your HRT if you’re on a weight-loss drug like Mounjaro® or Wegovy®.
⚖️ Safe Adjustment of Your HRT Regimen
We can transition you smoothly onto safer transdermal oestrogen, fit a Mirena® coil if appropriate, or advise on increasing oral progesterone doses.
📝 Ongoing Monitoring and Reassurance
We don’t just “set and forget.” We’ll make sure your bleeding patterns, symptoms, and blood tests are properly monitored.
💬 Expert Advice on Every Aspect of Menopause Care
From managing side effects to improving your quality of life—we’re here for the whole journey.
✨ Your Next Step: Prioritise Your Hormone Health Today
If you are on Mounjaro®, Wegovy®, or any GLP-1 agonist and you’re also using HRT, don’t leave things to chance.
Make sure your hormones—and your health—are fully protected.
👉 Book your specialist menopause review today with Essex Menopause Clinic.
We’ll assess your needs, adjust your treatment plan if necessary, and give you complete peace of mind.
🌸 Secure your personalised menopause care today.
🌸 Stay safe, stay strong, and stay supported with experts who understand.
