There are some women for whom HRT is unsuitable, e.g. women who have had oestrogen dependent cancer such as breast cancer, and some types of gynaecological cancers.
Medications which can be helpful for treating menopausal symptoms and which do not involve HRT include some antidepressant medications, e.g. Venlafaxine, Paroxetine, Fluoxetine, Sertraline, Escitalopram or Citalopram.
Other medications such as Gabapentin, Pregabalin, Clonidine and Oxybutynin can also be used.